Pyruvate suppresses PGC1α expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes
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Pyruvate suppresses PGC1α expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes
Sodium pyruvate can increase mitochondrial biogenesis in C2C12 myoblasts in a peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC1alpha)-independent manner. The present study examined the effect of 72-h treatment with sodium pyruvate (5-50 mM) or sodium chloride (50 mM) as an osmotic control on the regulation of mitochondrial substrate metabolism and biogenesis in C2C12 myo...
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IN THEIR ARTICLE, Philp and colleagues (8) show that supraphysiological levels of pyruvate have multiple effects on myotubes in vitro. In response to exogenous pyruvate, glucose uptake and glucose transporter 4 (GLUT4) expression were downregulated, as was content of peroxisome proliferator-activated receptorcoactivator-1 (PGC-1 ) mRNA and protein. At the same time, pyruvate treatment upregulat...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2010
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00438.2009